EFFICACY AND ADVERSE EFFECTS OF MEDICINAL MARIJUANA FOR CHRONIC NONCANCER PAIN: SYSTEMATIC REVIEW OF RANDOMISED CONTROLLED TRAILS.
Amol Deshpande, MD MBA, Angela Mailis-Gagnon, MSc MD FRCPC, Nivan Zoheiry, MD PhD, Shehnaz Fatima Lakha
Can Fam Physician. 2015 Aug; 61(8): e372-e381.
A review compiles a total of six randomised controlled trials of 226 patients assessing the use of medical marijuana in neuropathic pain. The review found that a low-dose medical marijuana is likely to help with chronic neuropathic pain when used in conjunction with traditional analgesics, including opioids and anticonvulsants. However, trials were limited by short duration and although well tolerated in the short term, the long-term effects of psychoactive and neurocognitive effects of medical marijuana remain unknown.
Pre-clinical studies documenting the anti-cancer effects of THC and its success in inhibiting cancer growth and spread have been on the rise. Clinical studies however are scarce as the psychoactive effects of THC can limit its medicinal and clinical use. Could non-psychoactive cannabinoids found in cannabis and hemp be the answer to treating cancer instead?
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